Table 1. Clinical and pathological features of patients.
| Case 1 | Case 2 | Case 3 | |
|---|---|---|---|
| Familiarity | AMI | — | — |
| Age | 57 | 65 | 70 |
| Clinical history | — | HBP, diabetes, gastritis | HBP |
| Tumour size | RSA | Ampulla of Vater | RSA |
| Phase | Metastatic | Metastatic | Adjuvant |
| Adjuvant therapy | No | No | Yes |
| Type | — | — | 5-FU |
| Procedure | — | — | Bolus |
| Advanced therapy | Yes | Yes | No |
| Type | CPT11/5-FU | CDDP/5-FU | — |
| Procedure | Bolus/continuous infusion | Bolus/continuous infusion | — |
| Symptom | Chest pain | Chest pain | Chest pain |
| Duration | Few minutes | 5 min | Few minutes |
| Cycle | 1° | 1° | 3° |
| Day | 4° | 4° | 4° |
| Therapy | Yes | Yes | Yes |
| Type | Nitroglycerin | Nitroglycerin | Nitroglycerin |
| Examinations | Yes | Yes | Yes |
| EKG | Negative | Ischaemic alteration | Negative |
| EchoCG | No | Reduction of contractility | No |
| Enzymes | Negative | Not done | Negative |
| Effort-EKG | No | Ventricular extrasystole | Negative |
| Other cycles | Yes | Yes | Yes |
| Number | 5 | 6 | 3 |
| Procedure | Bolus/continuous infusion | Bolus/continuous infusion | Bolus |
| Therapy | Nitroglycerin/dose reduction of 5-FU | Nitroglycerin/dose reduction of 5-FU | Weekly therapy |
| Other symptoms | No | No | No |
| Other chemotherapy | Yes | No | No |
| Type | OXP/5-FU | — | — |
| Procedure | Bolus/continuous infusion | — | — |
| Symptoms | No | — | — |
| Other cycles | Yes | — | — |
| Number | 6 | — | — |
| Procedure | Bolus/continuous infusion | — | — |
| Therapy | Nitroglycerin | — | — |
AMI=acute myocardial infarction; CPT11=irinotecan; EKG=electrocardiogram; echoCG=echocardiogram; CDDP=cisplatin; OXP=oxaliplatin; 5-FU=5-fluorouracil; HBP=high blood pressure; RSA=rectal–sigmoid adenocarcinoma.