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. 2003 May 27;88(11):1800–1807. doi: 10.1038/sj.bjc.6600984

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Copyright © 2003 Cancer Research UK

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Western blot analysis demonstrating marked cleavage of PARP (p85; A) and procaspase-3 (p17/p12; B) into its active fragments after combined exposure of clearCa-22 cells to TRAIL (10 ng ml⁻¹) and IR (1 Gy). Exposure to TRAIL or IR alone did not result in increased cleavage. No cleavage products of procaspases-6 (p15; C) and -7 (p17; D) in clearCa-22 cells after exposure to TRAIL or IR alone and in combination. (cleavage of PARP as well as the procaspase-3, -6, and -7 in J16 cells after exposure to CH11 (500 ng ml⁻¹) was used as a positive control). Expression of α-tubulin (E) shows equal amounts of protein loaded in each lane.