Table 3. Clinical and immunocytochemical findings in 25 pancreatic endocrine tumours.

					Metastases			Clinical outcome				ICC findings
	Case no.	Age	Sex	Hormonal Syndrome	Lgl	Liver	Years	NED	AWD	DWD	DOD	NESP55	CgA
Well-differentiated endocrine tumour
Insulinoma	16	62	M	Yes	—	—	1	X	0	0	0	2+	3+
	17	80	F	Yes	—	—	8	X	0	0	0	3+	3+
	18	17	F	Yes	—	—	3	X	0	0	0	3+	3+
	19	32	F	Yes	—	—	1	X	0	0	0	—	3+
	20	83	F	Yes	—	—	1	X	0	0	0	3+	3+
	21a	68	F	Yes	—	—	7	X	0	0	0	3+	3+
Glucagonoma	22	50	F	Yes	—	—	7	X	0	0	0	—	3+
Gastrinoma	23a	55	M	Yes	—	—	3	X	0	0	0	1+	3+
Nonfunctioning	24	63	F	No	—	—	4	X	0	0	0	—	3+
	25	63	M	No	—	—	1	X	0	0	0	2+	3+
	26	25	M	No	—	—	11	X	0	0	0	—	3+
	27	76	F	No	—	—	4	X	0	0	0	2+	3+
Well-differentiated endocrine carcinoma
Insulinoma	28	62	M	Yes	+	—	<1	0	0	Xb	0	3+	3+
	29	69	M	Yes	—	+	<1	0	0	Xc	0	1+	3+
Glucagonoma	30	49	M	Yes	+	—	6	X	0	0	0	—	3+
Gastrinoma	31	30	F	Yes	—	+	7	0	0	0	X	—	3+
Nonfunctioning	32	48	M	No	—d	—	2	0	X	0	0	1+	3+
	33a	55	M	No	+	—	2	0	X	0	0	—	2+
	34	53	M	No	+	+	3	X	0	0	0	1+	3+
	35	40	M	No	—	+	4	Xe	0	0	0	1+	3+
	36	49	M	No	+	—	4	0	X	0	0	1+	3+
	37	47	M	No	+	—	1	0	0	0	X	—	2+
	38f	55	F	No	+	—	5	X	0	0	0	—	3+
	39	58	F	No	+	+	5	0	X	0	0	—	3+
	40	45	F	No	+	+	7	Xg	0	0	0	—	3+

Age=age at diagnosis and primary surgery. F=female, M=male. Metastases: Lgl=lymph node metastases, liver=liver metastases. Clinical outcome: Years=observation time. X indicates outcome at follow up, which was categorized as NED=alive, no evidence of disease. AWD=alive with disease. DWD=dead with disease. DOD=dead of disease. ICC findings: The categories were as follows: 0=<1% positive cells, 1+=1–24% positive cells, 2+=25–75% positive cells, 3+=>75% positive cells.

^aMEN 1 syndrome.

^bDied postoperatively because of surgical complications.

^cDied from metastatic rectal carcinoma.

^dTumour invading large vessels.

^eTreated with orthotopic liver transplantation (OLT) following diagnosis, treated for local recurrence 3 years post-OLT, and treated for adrenal metastases 4 years post-OLT.

^fVon Hippel–Lindau syndrome.

^gTreated with orthotopic liver transplantation (OLT), 5 years after primary surgery because of liver metastases.