Figure 5.

Combined antiproliferative effect by treatment with rML and IR. E1A/ras-transformed p53-wild-type (A) and p53-deficient MEFs (B) were treated with rML (0.25 ng ml⁻¹) and IR (2 Gy) and the proliferative activity was assessed over 72 h after treatment with the MTT-like alamar blue assay. Irradiation was performed 1 h following rML treatment. The antiproliferative effect in the human SW480 cell line was also determined over 72 h after treatment with rML alone (C) or in combination with IR (D). Absence of error bars is due to minimal s.d.