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. 2003 May 27;88(11):1785–1792. doi: 10.1038/sj.bjc.6600982

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Copyright © 2003 Cancer Research UK

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p53-independent caspase-3-activation upon combined treatment with rML and IR. E1A/ras-transformed p53-wild-type (A) and p53-deficient (B) MEFs were treated with rML (0, 0.5, 1 ng ml⁻¹) alone or in combination with irradiation (2 Gy). Irradiation was performed 1 h after rML treatment and formation of active caspase-3 was determined in cytosolic extracts 18 h following irradiation using a specific antibody recognising the cleaved caspase-3 subunit.