Table 4. “Slow” reactions in the prototypic integrated system.

Description	Reactions	Excluded reactions	τdel (min)	τdur (min)
Degradation of phosphorylated compounds		—	—	40
Degradation of transcription factors		—	—	40
Production and degradation of additional proteins	vR	—	40	40
Internalization of ligand receptor complexes		,	40	6
Inhibitory reactions		,	40	6

The superscript S denotes signaling reactions. For example, S ₁ represents the set of reactions associated with the ligand L₁ (See Figure 1). The fluxes of excluded reactions in a given optimization instance are set to zero when the corresponding reactions participate in the network.