Table 1. Tumorigenicity in nude mice of human lung cancer cell line (PC10) or infected with gelsolin expression virus (LNChGsn) or neo-control virus (LNCX).
Tumour incidence |
Tumour volume at killing (days: 60, mean) (mm3) |
|||
---|---|---|---|---|
Cell line | Exp. 1 | Exp. 2 | Exp. 1 | Exp. 2 |
PC10 | 2/2 | 710 | ||
PN3 | 2/2 | 2/2 | 1128 | 1678 |
PG3 | 2/2 | 22 | ||
PG2 | 1/2 | 0/2a | 242 | 0 |
The indicated cells were grown as described in Materials and Methods. Two mice per clone were injected subcutaneously into the back with 3×106 cells in a final volume of 100 μl of BS. Tumour size was measured using a hand calipers every 10 days. Volumes were calculated as described in Materials and Methods.
Tumours were regressed at days 24 or 50 later Inoculation.