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. 2003 Feb 18;88(4):630–635. doi: 10.1038/sj.bjc.6600785

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Copyright © 2003 Cancer Research UK

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(A) Effect of Sant 7 on IL-6, IL-6sR or IL-6+IL-6sR-stimulated aromatase activity in fibroblasts derived from tissue proximal to a breast tumour. Fibroblasts were cultured in 2% stripped FCS, phenol red-free EMEM and treatments were added in this medium for 48 h in the presence of dexamethasone (100 nM). Aromatase activity was measured in intact monolayers using [³H-1β]androstenedione as the substrate. One set of cells (pretreatment) was preincubated with Sant 7 for 3 h before the addition of IL-6+IL-6sR, while for another set (no pretreatment) Sant 7 was added at the same time as IL-6+IL-6sR (a, P<0.001 vs controls; b, P<0.001 vs IL-6+IL-6sR, means±s.d., n=3). (B) Effect of Sant 7 on IL-6 or IL-6+IL-6sR-stimulated aromatase activity in fibroblasts derived from a breast tumour. Culture conditions were as described above (a, P<0.001 vs controls; b, P<0.001 vs IL-6+IL-6sR, means±s.d., n=3).