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. 2003 Feb 18;88(4):613–623. doi: 10.1038/sj.bjc.6600681

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Copyright © 2003 Cancer Research UK

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(A) HeLa cells subject to arginase treatment for 5 days; virtually no intact cells remain present except for a small clump (arrow) in which a large multinucleate cell is present. (B) Control HeLa cell culture in which no arginase was present for 5 days and has gone to confluence. (C) L1210 cells in a settled suspension from a culture after 3 days of arginase treatment; the majority of particles are shrivelled cells or free nuclei, with a few intact cells still present (small arrowheads), but several large, intact multinucleate (polyploid) cells are present in this particular field (large arrowheads). Nuclei remain in culture when L1210 cells break down because of the paucity of lysosomal enzymes. (D) Control L1210 cells, seen in the plane of focus in suspension. The images are all phase-contrast micrographs of living cultures. Magnifications are approximately ×200 for all panels.