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. Author manuscript; available in PMC: 2009 Jan 11.
Published in final edited form as: Drug Alcohol Depend. 2007 Oct 24;93(1-2):63–71. doi: 10.1016/j.drugalcdep.2007.08.020

Figure 1. Substitution and blockade of the discriminative stimulus effects of nicotine (0.4 mg/kg, i.p.).

Figure 1

Top panels show percent nicotine-lever appropriate responding. Bottom panels show rate of responding (r/s). Nicotine and methamphetamine fully substituted for the discriminative stimulus effects of nicotine (left panels). Nicotine increased response rates, whereas methamphetamine decreased rates. Asterisks show response rates different from vehicle control (p<0.05). Mecamylamine fully blocked the discriminative stimulus effects of nicotine, whereas haloperidol had no effect (right panels). Mecamylamine did not change response rates, whereas haloperidol dose-dependently decreased rates. N=10 except where shown. Asterisks indicate response rates different from nicotine control (p<0.05). Nic=nicotine; Meth=methamphetamine. Hal= haloperidol; Mec=mecamylamine. Ctrl=control.