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. 2008 May 21;3(5):e2267. doi: 10.1371/journal.pone.0002267

Figure 2. Effect of NAMPT inhibition with APO866 on established collagen-induced arthritis.

Figure 2

(a) Dose-response effect of APO866: test mice were treated twice daily ip with APO866 2, 5, or 10 mg/kg (n = 10 in each group) during 15 days. Placebo mice received vehicle only (n = 10). (b) Severity of arthritis in CIA mice receiving APO866 10 mg/kg ip twice daily or etanercept 15 mg/kg every three days (n = 10 in each group) over 15 days. Mice groups were compared by two-way ANOVA. *P<0.05 APO866 or etanercept versus placebo in panel a and b.