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. Author manuscript; available in PMC: 2009 Apr 15.
Published in final edited form as: Cancer Res. 2008 Apr 15;68(8):2632–2640. doi: 10.1158/0008-5472.CAN-07-5460

Figure 5.

Figure 5

Activation of the IKKβ/TSC1/mTOR pathway was observed in an orthotropic animal model. A, in rats, the relative expression density of pIKKβ (S181) was 1.5 times higher in inflammatory BE and 3.4 times higher in EAC. The relative expression density of pS6K1 (T389) was 1.6 times higher in BE and 2.8 times higher in EAC compared with normal esophagus squamous epithelia (NE). B, immunohistochemical staining revealed the expression of pIKKβ (S181) and pS6K1 (T389) in BE and EAC. pIKKβ (S181) and pS6K1 (T389) staining in the adjacent NE was negative.