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Effect of COX inhibitors on carrageenan-induced edema and hyperalgesia in the rat footpad. A single dose of 30 mg/kg SC-560, celecoxib, or vehicle was administered by oral gavage 2 hr before initiation of inflammation with carrageenan. Edema (■, left axis) and hyperalgesia (□, right axis) were measured 6 hr after carrageenan injection. Data shown are the mean (n = 5) ± SEM and are from one of three experiments with similar results.
