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Effect of COX inhibitors on carrageenan-induced PGE2 in the rat footpad. A single dose of 30 mg/kg SC-560, celecoxib, or vehicle was administered by oral gavage either 2 hr before (■) or 3 hr after (□) carrageenan injection. Paw inflammatory fluid was collected and PGE2 was quantified by ELISA. Data represent mean (n = 5) ± SEM and are from one of three experiments with similar results.
