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Inhibition of TxB2 in ex vivo calcium ionophore-stimulated whole blood
| TxB2 ng/ml
|
||
|---|---|---|
| −Ionophore | +Ionophore | |
| Vehicle | 0.65 ± 0.1 | 4.5 ± 0.8 |
| Indomethacin (10 mg/kg) | 0.92 ± 0.2 | |
| SC-560 (30 mg/kg) | 0.62 ± 0.1 | |
| Celecoxib (30 mg/kg) | 4.4 ± 1.4 | |
Compounds were administered orally 1 hr before sample collection. Whole blood collected from animals (n = 4) was stimulated with calcium ionophore A23187. Plasma was prepared and TxB2 was quantified by ELISA. Data are reported as the mean ± SEM.
