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. 2008 May 5;105(19):7076–7081. doi: 10.1073/pnas.0802615105

Fig. 5.

Fig. 5.

A mutation in Disc1 leads to specific pattern of cognitive deficits. (A) Fear conditioning. (Left) Conditioned freezing during the cued test (n = 9 WT, 9 HOM). Percent of time freezing during the 60 s before tone presentation (pretone) and during the 20-s tone presentation (tone). (Right) Percent time freezing during the 4 min of the contextual test. (B) Novel object recognition. Although the ability to recognize a familiar object significantly decreased with time, there were no differences between genotypes (n = 9 WT, 9 HOM). (C) Morris water maze. (Left) Latency to reach a visible platform did not differ between genotypes (n = 9 WT, 9 HOM). (Center and Right) Both genotypes spent more time in the target quadrant during the probe trials. (D) Win-shift task. Both genotypes made comparable numbers of within-phase (Left) and across-phase (Right) errors (n = 9 WT, 9 HOM). (E) Two-choice DNMP task. Both HET and HOM mutant Disc1 mice made significantly more errors during training (Left) and testing (Right; n = 10 WT, 11 HET, 11 HOM). Values represent mean ± SEM. n.s., not significant; ∗, P < 0.05.