Table 1.
Genes with a conserved role in innate immunity regulation
| Mouse gene | C. elegans gene* | Macrophage† | C. elegans‡ | Drosophila§ | Mouse | Other |
|---|---|---|---|---|---|---|
| Heca | cri-1=K07A1.7 | IL-6, TNF | clec-85 | |||
| Tulp4 | tub-2 = tag-305 | IL-6 | clec-85 P. aeruginosa | Systemic LPS¶ | Expression correlates with other immune response genes (57) | |
| Macf1 | vab-10 | IL-6, TNF | clec-85 | Overexpressed in patients infected with Parvovirus B19 (58) | ||
| Psmd3 | rpn-3 | IL-6, TNF | clec-85 | Diptericin, NFκB | Binds Traf6, NFκB (59) | |
| Timp3 | cri-2 = tag-225 | IL-6 | clec-85 | Regulates cyokines (60,61) | ||
| Tbc1d23 | tbc-1 | IL-6, TNF | clec-85 P. aeruginosa | Lung LPS‖ | ||
| Rpl22 | rpl-22 | IL-6 | clec-85 | Diptericin | Induced in daf-2(−) (62) | |
| Adcy9 | acy-1 | IL-6, TNF | clec-85 P. aeruginosa | Diptericin | cAMP regulates cytokines (39–42) | |
| Rps27 | rps-27 | IL-6 | clec-85 | Induced in daf-2(−) (62) | ||
| C1qbp | cri-3 = F59A2.3 | IL-6, TNF | clec-85 | |||
| Siah1a | siah-1 | IL-6, TNF | clec-85 | Regulates NFκB (33) |
*Because these genes are conserved regulators of innate immunity, we designate the previously unnamed C. elegans genes K07A1.7, tag-225, and F59A2.3 as cri-1, cri-2, and cri-3, respectively, and rename tag-305 as tub-2, for the second C. elegans member of the Tubby family.
†siRNA treatment regulates Il-6 and/or TNF-α production as indicated (this work).
‡RNAi treatment regulates clec-85::gfp expressission . P. aeruginosa indicates that the mutant is susceptible to pathogen (this work).
§Diptericin indicates genes that regulate the LPS-induced production of that antimicrobial in Drosophila; Psmd3 also regulates LPS-induced NFκB nuclear translocation in Drosophila (14).
¶Induced in mouse organs by systemic LPS exposure (I. Yang and D.A.S., unpublished data).
‖Induced in mouse lung tissue by LPS exposure (10).