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. 2008 May 12;105(19):7028–7033. doi: 10.1073/pnas.0710595105

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© 2008 by The National Academy of Sciences of the USA

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Fig. 2. — Flux parameters relevant to citrate synthesis and mitochondrial citric acid cycle (CAC) intermediates in isolated working mdx and mdx/GC^+/0 mouse hearts. Data are means ± SEM of perfusion experiments performed in isolated working mdx (solid bars) and mdx/GC^+/0 (open bars) mouse hearts (n = 4 per group). Procedures for the determination of (A) the contribution of carbohydrates (lactate, pyruvate, and glucose) and exogenous fatty acids (oleate) to acetyl-CoA formation for citrate synthesis (CS) via pyruvate decarboxylation (PDC) and β-oxidation (OLE), respectively referred to as PDC/CS and OLE/CS and (B) tissue levels of CAC intermediates are described in Materials and Methods. *, P < 0.05 mdx vs. mdx/GC^+/0 mouse hearts.