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Heart rate responses and in vivo cardiomyocyte sarcolemmal injury induced by an acute increase in cardiac mechanical stress in placebo vs. sildenafil-treated mdx mice. Values are means ± SEM of four to six experiment in placebo (solid bars) or sildenafil-treated (open bars) mdx mouse hearts, as described in Fig. 3. *, P < 0.05; **, P < 0.01, #, P < 0.001 for placebo vs. sildenafil-treated mdx mouse hearts.
