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The functional consequences of the mutation in Btk were evaluated in a chicken B cell line, DT40, stimulated with anti-IgM. (a) Calcium flux in wild-type (Btk+) DT40, Btk– DT40, Btk– DT40 transfected with wild-type Btk and Btk– DT40 transfected with the variant Btk (left to right). (b) Inositol triphosphate (IP3) generation at the time intervals shown.
