Table 2.
Medians of half-life, IVR, IR, Cmax, Tmax, AUC and CL for total serum IgG and tetanus antibody titre with 95% confidence intervals.
| Parameter | Median total serum IgG (with 95% CI) | Median tetanus antibody titre (with 95% CI) |
|---|---|---|
| Half-life days | 40·6 days (CI from 20·1 to 56·1 days) | 23·3 days (CI from 12·7 to 31·3 days) |
| IVR % | 35·8% (CI from 18·1 to 56·4%) | 45·6% (CI from 38·1 to 55·6%) |
| IR g/ml | 7·3 g/ml (CI from 3·8 to 12·4 g/ml) | 9·1 g/ml (CI from 8·4 to 11·3 g/ml) |
| Cmax mg/dl | 8·82 g/l (CI from 8·31 to 10·32 g/l) | 15·5 IU/ml (CI from 14 to 17 IU/ml) |
| Tmax days | 4 days (CI from 4 to 8 days) | 4 days (CI from 2 to 8 days) |
| AUC days × mg/dl | 11 400 days × mg/dl (CI from 10 200 to 11 800 day × mg/dl) | 179 days × IU/ml (CI from 165 to 199 day × IU/ml) |
| CL ml/kg/day | 1·7 ml/kg/day (CI from 1·6 to 1·9 ml/kg/day) | 4·0 ml/kg/day (CI from 3·6 to 4·3 ml/kg/day) |
CI, confidence intervals; IVR, in vivo recovery; IR, incremental recovery; Cmax, maximum concentration; Tmax, time to reach maximum concentration; AUC, area under the curve; CL, clearance. IgG, immunoglobulin G.