Table 2.
Normal and apoptotic intrahepatic natural killer (NK)/NK T cell ratios in pathogenic L2-mouse hepatitis virus type 3 (MHV3)-, low attenuated 51·6-MHV3-, highly attenuated CL12-MHV3- and non-pathogenic YAC-MHV3-infected C57BL/6 mice at various times post-infection.
| Times post-infection (h) | ||||
|---|---|---|---|---|
| Cell populations | Viral infection† | 24 | 48 | 72 |
| Normal cells | Mock-infected | 0·94 ± 0·04 | 1·45 ± 0·11 | 1·35 ± 0·07 |
| L2-MHV3 | 1·51 ± 0·10* | 2·14 ± 0·95 | 1·54 ± 0·31 | |
| 51·6-MHV3 | 1·38 ± 0·17* | 3·72 ± 0·49** | 0·86 ± 0·19* | |
| CL12-MHV3 | 1·39 ± 0·23* | 1·67 ± 0·09 | 1·46 ± 0·25 | |
| YAC-MHV3 | 1·18 ± 0·24 | 1·36 ± 0·11 | 1·43 ± 0·04 | |
| Apoptotic cells | Mock-infected | 0·49 ± 0·14 | 0·68 ± 0·03 | 1·67 ± 0·62 |
| L2-MHV3 | 0·40 ± 0·18 | 2·63 ± 0·61** | 3·97 ± 0·61** | |
| 51·6-MHV3 | 0·92 ± 0·69 | 3·01 ± 0·25*** | 1·73 ± 0·48 | |
| CL12-MHV3 | 0·61 ± 0·11 | 1·25 ± 0·10* | 1·73 ± 0·22 | |
| YAC-MHV3 | 0·62 ± 0·20 | 1·48 ± 0·18* | 2·04 ± 0·31 | |
P < 0·05
P < 0·01
P < 0·001.
Three mice were used in each experimental group. The ratios of percentages of NK and NK T cells from MHV3-infected mice were compared with those from mock-infected mice.