Fig. 5.

The effect of lidocaine on phorbol myristate acetate + phytohaemagglutitin (PMA + PHA)-stimulated interleukin (IL)-2 secretion from peripheral blood (PB) T cells. PB T cells obtained from healthy donors were stimulated by PMA + PHA, and then cultured in the absence or presence of graded concentrations of lidocaine. IL-2 level in the supernatant was determined at 24 h by enzyme-linked immunosorbent assay. Results obtained from six different donors are shown. IL-2 secretion was reduced significantly between all different lidocaine concentrations at P = 0·03 for trend, using the Wilcoxon rank test. NC: negative control (non-stimulated cells).