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LBH589 induces hyperacetylation of histones H3K9 and H4K8, and modulates expression of cell-cycle control genes. Cells were treated with indicated concentrations of LBH589 for 24 hours. After this, Western blot analyses of acetylated histones H3K9 and H4K8, p21, p27, and c-Myc were performed on the cell lysates from MOLT-4 cells (A) and Reh cells (B). The levels of β-actin served as loading control. Results are representative of 3 independent experiments.
