Table 2.
Distribution of allele markers in each class of GAA repeat length
| Marker | Allele | Chromosome
|
|||||
|---|---|---|---|---|---|---|---|
| SN
|
LN
|
E
|
|||||
| n | % | n | % | n | % | ||
| FAD1 | C | 144 | 91.1 | 8 | 12.9 | 11 | 10.3 |
| A* | 14 | 8.8 | 54 | 87.1 | 96 | 89.7 | |
| ITR4 | T* | 49 | 30.4 | 57 | 91.9 | 103 | 95.4 |
| C | 112 | 69.6 | 5 | 8.0 | 5 | 4.6 | |
| F5225† | −1 | 3 | 0 | 0 | |||
| 0 | 2 | 1 | 0 | ||||
| 1 | 42 | 27.3 | 7 | 11.5 | 4 | 3.74 | |
| 2* | 57 | 37.0 | 46 | 75.4 | 78 | 72.9 | |
| 3 | 44 | 28.6 | 7 | 5.8 | 25 | 11.7 | |
| 4 | 3 | 0 | 0 | ||||
| 5 | 2 | 0 | 0 | ||||
| 6 | 1 | 0 | 0 | ||||
| ITR3 | C* | 76 | 49.4 | 58 | 96.7 | 107 | 100 |
| T | 78 | 50.6 | 2 | 3.3 | 0 | ||
| CS2 | C | 114 | 75.0 | 43 | 71.7 | 89 | 84.0 |
| T | 38 | 25.0 | 17 | 28.3 | 17 | 16.0 | |
In a minority of cases, alleles could not be characterized because of noninformative markers for phase determination.
*
Significantly associated with LN (P < 0.001) and E (P < 0.001) chromosomes.
†
Alleles are numbered by decreasing number of (TCTA)n + (TCCA)n repeats, with allele −1 having 19 tetranucleotide repeats, according to the initial description of this microsatellite (17). χ2 calculation was performed with the allele 2 compared to the pooled other alleles.