TABLE 2.
Results of blood analysis of vector-treated dogs*
| Adenovirus (bolus)
|
DNA/PEI (bolus)
|
Naked DNA (bolus)
|
DNA/PEI (10 mins)
|
DNA/PEI (10 mins)
|
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Test | Ref Range |
Preop | 24 Hrs |
72 Hrs |
Preop | 24 Hrs |
72 Hrs |
Preop | 24 Hrs |
72 Hrs |
Preop | 24 Hrs |
72 Hrs |
Preop | 24 Hrs |
72 Hrs |
| blood urea nitrogen (mg/dl) | 9–31 | 19 | 18 | 18 | 19 | 25 | 15 | 16 | 6 | 12 | 20 | 12 | 10 | 21 | 9 | 10 |
| creatinine (mg/dl) | 0.6–1.6 | 0.9 | 0.7 | 0.7 | 0.6 | 0.9 | 0.7 | 0.6 | 0.4 | 0.6 | 0.7 | 0.5 | 0.7 | 0.7 | 0.5 | 0.7 |
| calcium (mg/dl) | 9.3–11.5 | 10.6 | 10.5 | 10.7 | 10.1 | 10.6 | 10.6 | 10.4 | 10.3 | 10.5 | 10.8 | 10.5 | 11.1 | 10.5 | 10.2 | 10.5 |
| phosphorus (mg/dl) | 3.3–6.8 | 5.3 | 5.7 | 5.9 | 7.4 | 6 | 5.6 | 4.7 | 5.2 | 5.8 | 6.5 | 4.6 | 6 | 6.2 | 5.4 | 6.1 |
| magnesium (mg/dl) | 1.7–2.4 | 1.7 | 1.8 | 1.6 | 1.6 | 1.9 | 1.7 | 1.7 | 1.6 | 1.7 | 1.7 | 1.9 | 1.9 | 1.7 | 1.8 | 1.6 |
| sodium (mmol/L) | 145–153 | 147 | 145 | 146 | 147 | 147 | 146 | 144 | 143 | 144 | 148 | 144 | 144 | 147 | 148 | 146 |
| chloride (mmol/L) | 109–118 | 108 | 111 | 109 | 114 | 114 | 112 | 106 | 111 | 107 | 109 | 105 | 103 | 110 | 112 | 110 |
| potassium (mmol/L) | 3.6–5.3 | 3.4 | 3.9 | 4 | 4.3 | 4.9 | 4.3 | 4.2 | 4.5 | 4.7 | 3.5 | 3.8 | 4.1 | 4.4 | 4.2 | 4.7 |
| bilirubin total | 0–0.3 | 0.2 | 0.2 | 0.2 | 0.1 | 0.1 | 0.2 | 0.2 | 0.2 | 0.1 | 0.2 | 0.2 | 0.2 | 0.2 | 0.2 | 0.2 |
| alkaline phosphatase (U/L) | 8–139 | 79 | 81 | 80 | 61 | 100 | 80 | 82 | 162 | 139 | 54 | 138 | 103 | 93 | 167 | 129 |
| gamma glutamyl transferase (U/L) | 0–6 | <3 | <3 | <3 | <3 | 3 | <3 | <3 | 3 | 3 | <3 | <3 | <3 | <3 | 3 | <3 |
| alanine transaminase (U/L) | 22–92 | 57 | 61 | 55 | 30 | 34 | 35 | 30 | 41 | 38 | 55 | 78 | 49 | 30 | 25 | 28 |
| aspartate transaminase (U/L) | 16–44 | 23 | 59 | 15 | 22 | 28 | 20 | 20 | 41 | 19 | 29 | 52 | 15 | 22 | 21 | 17 |
| glucose (mg/dl) | 75–117 | 113 | 108 | 101 | 113 | 94 | 101 | 103 | 111 | 87 | 111 | 115 | 108 | 99 | 111 | 96 |
| cholesterol (mg/dl) | 143–373 | 188 | 180 | 199 | 164 | 196 | 198 | 181 | 181 | 203 | 213 | 256 | 271 | 243 | 245 | 264 |
| amylase (U/L) | 275–1056 | 739 | 657 | 738 | 623 | 575 | 608 | 543 | 415 | 583 | 545 | 380 | 462 | 752 | 467 | 634 |
| WBCs (× 103/μl) | 4.1–13.3 | 8.6 | 11.6 | 12 | 6.6 | 10.6 | 7 | 8.9 | 11.5 | 9.9 | 9.9 | 17.2 | 9 | 10.4 | 15.5 | 9.9 |
| neutrophils, segmented (× 103/μl) | 2.1–11.2 | 5.76 | 9.51 | 9.24 | 3.89 | 8.27 | 3.71 | 3.83 | 8.17 | 6.14 | 6.34 | 15.14 | 6.03 | 7.07 | 13.49 | 6.83 |
| neutrophils, bands (× 103/μl) | 0–0.13 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| lymphocytes (× 103/μl) | 0.3–5.1 | 2.06 | 1.39 | 1.56 | 1.65 | 1.7 | 2.45 | 3.56 | 2.19 | 2.38 | 2.87 | 0.69 | 2.16 | 2.39 | 1.24 | 2.48 |
| monocytes (× 103/μl) | 0–1.2 | 0.6 | 0.58 | 0.72 | 0.73 | 0.64 | 0.84 | 1.51 | 1.15 | 1.19 | 0.69 | 1.38 | 0.54 | 0.62 | 0.62 | 0.2 |
| eosinophils (× 103/μl) | 0–1.2 | 0.17 | 0.12 | 0.48 | 0.33 | 0 | 0 | 0 | 0 | 0.2 | 0 | 0 | 0.27 | 0.31 | 0.16 | 0.2 |
| basophils (× 103/ml) | 0–0.13 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.2 |
| hemoglobin (g/dl) | 13.5–19.9 | 15.4 | 12.7 | 13.9 | 14.6 | 14.3 | 13.9 | 15.5 | 16.5 | 17.6 | 14.9 | 15.8 | 16 | 14.2 | 14.1 | 14.2 |
| hematocrit (%) | 38.5–56.7 | 44.3 | 36.4 | 40.2 | 42.6 | 40.3 | 40.6 | 45.2 | 47.9 | 50.5 | 43.2 | 45 | 45.9 | 40.8 | 40.2 | 40.7 |
| platelets (× 103/μl) | 160–425 | 255 | 256 | 259 | ND | 307 | 296 | 228 | 214 | 270 | 283 | 306 | 354 | 378 | 410 | 429 |
ND = no data; Ref= reference.