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Polyalanine tract sequence in 20 SPD pedigrees. Across the top is a normal 15-residue sequence. Below the sequence are expansions (boxed) in SPD pedigrees. Probable sites of insertion of duplicated regions are indicated by vertical arrows. Note that many of these expansions could be interpreted as insertions of the same-sized duplications at a different site. Alanine 12 is encoded by GCG in pedigrees B, G–J, M, O, and P.
