Figure 5.

Random-effects meta-regression evaluating effect of NEDAs on mean change in IRLS (A) and CGI-I (B) over time.

NEDAs = nonergot dopamine agonists; IRLS = International Restless Legs Syndrome Study Group Scale; CGI-I = Clinical Global Impression-Improvement; RR=relative risk.

Note: The circles represent individual studies, and the area of the circle is proportional to the weight of each study. The dark line represents the regression equation as represented by the following equation: (A) weighted mean difference = −11.3545 + 0.6574 × study duration; (B) LnRR=0.5304–0.0219 × study duration.