Table.
Baseline Characteristics of Responders and Non-Responders to Riluzole and Healthy Volunteers
| Responders (n = 9) | Non-Responders (n= 5) | Healthy Volunteers (n= 7) | |
|---|---|---|---|
| Age | 32 (3.9) | 31 (2.5) | 27 (1.6) |
| Female | 5/9 (56%) | 3/5 (60%) | 5/7 (71%) |
| w/ ≥ 1 comorbid AD | 6/9 (67%) | 3/5 (60%) | 0/7 (0%) |
| Psychotropic-naive | 4/9 (44%) | 2/5 (40%) | 0/7 (0%) |
| Abuse history | 1/9 (11%) | 2/5 (40%) | 2/7 (29%) |
| Body Mass Index | 23.4 (4.4) | 21.1 (1.2) | 21.9 (.61) |
| IQ | 117.0 (3.5) | 119.5 (6.2) | 123.0 (3.8) |
| Age of onset | 16.1 (3.6) | 19.7 (4.6) | N/A |
| Duration of illness | 15.9 (3.8) | 11.5 (3.1) | N/A |
| HAM-A | 19.2 (1.0) | 21.4 (2.0) | 1.7 (.64)* |
| PSWQ | 66.0 (2.6) | 62.0 (4.2) | 31.0 (3.6)* |
| HRSD24 | 14.8 (1.8) | 15.2 (0.9) | 1.3 (.57)* |
Note: Standard errors are in parentheses. AD = anxiety disorder (panic disorder, social phobia, or specific phobia); self-reported childhood abuse history as per modified version of Early Trauma Inventory (see 33); IQ = Wechsler Abbreviated Scale of Intelligence full scale score; HAM-A = Hamilton Anxiety Rating Scale; PSWQ = Penn State Worry Questionnaire; HRSD24 = 24-item Hamilton Rating Scale for Depression.
*
Healthy volunteers differ from responders and non-responders, p < .001.