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. 2008 May 14;105(20):7188–7193. doi: 10.1073/pnas.0708044105

Fig. 2.

Fig. 2.

Modulation of polyamine levels affects α9-dependent enhanced migration. (a) Levels of polyamines from cells treated for 2 d with 5 mM DFMO with or without 100 μM putrescine. (b) α9- or α9α5-expressing CHO cells were treated as in a, and migration on TNfn3RAA was measured after 3 h. *, P = 2.2 × 10−10; **, P = 9.8 × 10−8. (c) α9- or α9α4-expressing MEFs were treated or not with three different siRNAs to PAO and induced to migrate on TNfn3RAA. *, P = 2.0 × 10−4; **, P = 0.014. (d) Migration of α9-transfected MEF cells treated with siRNA to PAO as in c, with or without additional treatment with 100 μM putrescine. *, P = 8 × 10−16; **, P = 1.1 × 10−16.