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. 2008 May 19;181(4):639–653. doi: 10.1083/jcb.200708004

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© 2008 Kawahara et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 7. — A working model for targeted translational repression by Msi1. Msi1 interacts with the 3′ UTR of its target mRNA and PABP, and subsequently inhibits translation initiation by competing with eIF4G for PABP. These sequential events inhibit formation of the 80S ribosome complex.