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. 2008 May 19;181(4):697–709. doi: 10.1083/jcb.200801101

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© 2008 Paterson et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 8. — A model for the role of Fus2p in cell fusion. Cytoplasmic Fus2p associates with Rvs161p and attaches to vesicles (ves) as it is transported to the shmoo tip along actin cables by a myosin (myo). Fus2p/Rvs161p would be tethered to the cortex by Fus1p. Fus2p then acts as a Rho-GEF, activating a putative Rho-GTPase to trigger vesicle fusion with the plasma membrane. Cell wall (cw) hydrolytic enzymes, carried by the vesicles, would be released into the extracellular space to degrade the intervening cell wall, allowing plasma membranes (pm) to fuse in subsequent steps.