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Warm threshold. The overall four-factor repeated measures ANOVA revealed a significant main effect of location ¶(F [1, 15] = 82.9, p < 0.0001), significant main effect of time* (F [3, 45] = 35.7, p < 0.0001), and a significant interaction of location and time (F [3, 45] = 8.0, p < 0.001). The main effect of location was accounted for by the significantly higher thresholds in calf versus thigh at all time points.
