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. Author manuscript; available in PMC: 2009 Apr 1.
Published in final edited form as: Mol Cell Neurosci. 2007 Dec 15;37(4):696–707. doi: 10.1016/j.mcn.2007.12.015

Figure 1.

Figure 1

Pitx2cre; N-lacZ lineage tracing approach labels Pitx2 mutant neurons. (A) Pitx2cre/+ embryos were mated with Pitx2+/null; N-lacZ/N-lacZ mice to yield embryos of four possible genotypes. Pitx2cre/+;N-lacZ (B) and Pitx2cre/null:N-lacZ (C) embryos express β-galactosidase in Pitx2-expressing tissues at E12.5, including the eye, hypothalamus (hyt), midbrain (mb), heart (h), craniofacial structures, and somites. Pitx2cre/null;N-lacZ embryos exhibit lethality after E14.5, likely due to cardiac and abdominal defects that are not well visualized in this sagittally oriented embryo (C).