Table 2. Functional annotation of CPGs subject to positive selection.

Description	CPGs	Predicted Location	Size a	Pfam Domains	Biological Process	Molecular Function
65 kDa ISG	19416372, 21719250	Su	434–436	n/d	n/d	n/d
75 kDa ISG	20195704	Su	522–523	n/d	n/d	n/d
Adenosine transporter	20117965	Su	462–466	MFS_1, Nucleoside_tran	transport	nucleoside transporter activity
Amino acid transporter	19796418, 22063411	Su	450–490	Aa_trans, Trp_Tyr_perm	amino acid transport	amine transmembrane transporter activity
EP1 procyclin	19416463	Su	123–141	n/d	n/d	n/d
GRESAG2	20975481	Su	454–457	n/d	n/d	n/d
Receptor-type AC	19651441, 20115358, 21139502, 21943524	Su, Se	1170–1288	Guanylate_cyc	intracellular signalling cascade, cyclic nucleotide biosynthetic process	phosphorus-oxygen lyase activity
RHS	19651414, 20343633, 20439293, 20461581, 20529562, 21995461	Se, Su, In	557–860	n/d	n/d	n/d

Predicted cellular location based on GPI signal peptide and transmembrane domain prediction for each member of each cluster (see methods) Su; surface, Se; secreted, In; Intracellular. Pfam domains were detected using HMMER [47] to search the Pfam database [54]. Gene Ontology terms were linked to predicted Pfam domains using Pfam2GO (http://www.geneontology.org/). For details of gene annotation and prediction of location see methods.