Skip to main content
. Author manuscript; available in PMC: 2008 May 15.
Published in final edited form as: Am J Physiol Renal Physiol. 2008 Feb 27;294(5):F1050–F1058. doi: 10.1152/ajprenal.00461.2007

Figure 6. TLR9 inhibition by phosphorothioate oligodeoxynucleotides improves acute kidney injury, multiple organ damage, and serum cytokines.

Figure 6

Mice were subjected to sham surgery (white bars, N = 5) or CLP (black bars, N = 8), and CLP was treated with control (A151, hatched bars, N = 8) or TLR9-selective (H154, gray bars, N = 8) phosphorothioate oligodeoxynucleotides, and evaluated at 24 hr for (A) kidney function (B) ALT, AST (C) amylase, CK, LDH (D) Number of active caspase3 positive cells in the spleen (E) TNF-alpha and IL-10. Values are mean ± SE. *, P < 0.05 vs. wild-type.