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. 2008 May 21;3(5):e2237. doi: 10.1371/journal.pone.0002237

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Hunter et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) ThyA converts dUMP to TMP using mTHF as a cofactor. mTHF is regenerated by dihydrofolate reductase (DHFR) and serine hydroxymethyltransferase (SHMT). (B) ThyX converts dUMP to TMP using mTHF, NADPH, and FAD as cofactors. mTHF is regenerated by SHMT.