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Consensus sequence with putative ORF from MSRV pol clones. The region corresponding to the PRT ORF cloned in a recombinant vector and expressed in Escherichia coli is boxed. The regions corresponding to the A and B fragments amplified from plasma samples from MS patients are indicated by brackets. The RT and RNase H (RNH) region is boxed with a dotted line. The highly conserved amino acids and/or active sites of enzyme activities of both PRT and RT (including RNH) are underlined.
