Table 3.

HRs for End-Stage Renal Disease (N = 136 cases) and Natural Mortality (N = 179 deaths)

		End-Stage Renal Disease		Natural Mortality
Model		HR 95% CI		HR 95% CI
1	Doubling of ACR−1	1.60	1.49–1.72	1.19	1.12–1.26
2	Doubling of ACR0	1.75	1.62–1.89	1.19	1.13–1.26
3	Doubling of ACR−1	1.06	0.95–1.17	1.05	0.95–1.16
	Doubling of ACR0	1.70	1.52–1.87	1.15	1.06–1.26
4	Baseline antihypertensive medication (0 or 1)	2.16	1.49–3.13	1.73	1.26–2.39
	Doubling of ACR−1	1.02	0.92–1.13	1.01	0.92–1.12
	Doubling of ACR0	1.71	1.54–1.89	1.16	1.07–1.27
5*	Age (/10 y)	0.90	0.79–1.13	1.74	1.49–2.03
	Sex (0 or 1)	1.15	0.78–1.69
	Diabetes duration (/5 y)	1.42	1.23–1.65	1.15	1.02–1.29
	Baseline antihypertensive medication (0 or 1)	2.64	1.77–3.93	1.96	1.41–2.73
	Mean arterial pressure (/1 mm Hg)	1.00	0.99–1.02	1.00	0.99–1.01
	Body mass index (/1 kg/m2)	0.97	0.94–1.00	0.97	0.94–1.00
	Doubling of ACR−1	1.00	0.90–1.13	1.00	0.91–1.12
	Doubling of ACR0	1.70	1.50–1.91	1.16	1.05–1.28

Note: Models 1, 2, and 3 adjusted for sex, baseline age, and diabetes duration. Model 4 adjusted for sex, baseline age, diabetes duration, and antihypertensive medication.

Abbreviations: ACR, albumin-creatinine ratio; HR, hazard ratio; CI, confidence interval; ACR₀, second ACR measurement; ACR₋₁, first ACR measurement.

^*The full model for end-stage renal disease was stratified by hemoglobin A_1c tertiles, and the full model for natural mortality was stratified by sex and hemoglobin A_1c tertiles.