Fig. 5.
Histopathology of scarred gastric ulcer before and after IL-1β injection according to treatment. Gross observation before IL-1β injection at 28 weeks after acetic acid induced gastric ulcer showed that all acetic acids-induced gastric ulcers become scarring stage (S1 or S2 stage) irrespective of group. However, histopathological observations were differed so much according to group. Dilated and distorted gastric glands were noted in both Group I (naturally healed) and Group II (PPI-treated group), whereas normal looking restored gastric mucosa was seen in Group III (DA-9601 treated group). Significant infiltrations of inflammatory cells and denuded mucosal layers were seen after IL-1β injection in Group I and II, but attenuated inflammatory response and conserved mucosal layer were seen in Group III, signifying that excellent remodelling of regenerated gastric mucosa, hard to discriminate between intact gastric mucosa and regenerated gastric mucosa, was achieved in rats treated with gastroprotectants and might be responsible for resistance to ulcer recurrence after IL-1β injection.