Table 2.

Frequency of PIK3CA Mutation in Colorectal Cancer.

Clinical/Pathologic Feature	n	PIK3CA Mutation [n (%)]	OR (95% CI)	P
All cases, N	590	91 (15)
Gender
Men	272	43 (16)	1
Women	318	48 (15)	0.95 (0.61–1.48)
Age, yr
<59	147	19 (13)	1
60–69	244	37 (15)	1.20 (0.66–2.18)
≥70	198	35 (18)	1.45 (0.79–2.65)
Location
Proximal	244	46 (19)	1
Distal	324	43 (13)	0.66 (0.42–1.04)
Tumor stage
I	134	21 (16)	1
II	165	28 (17)	1.10 (0.59–2.04)
III	160	27 (17)	1.09 (0.59–2.04)
IV	67	9 (13)	0.84 (0.36–1.94)
Differentiation
Well	179	44 (25)	1	Referent
Moderate/Poor	407	47 (12)	0.40 (0.25–0.63)	<.0001
Mucinous component
Absent	325	36 (11)	1	Referent
Present (≥1%)	189	44 (23)	2.44 (1.50–3.95)	.0002
Signet ring cells
Absent	449	67 (15)	1
Present (≥1%)	38	6 (16)	1.07 (0.43–2.66)

CI indicates confidence interval; OR, odds ratio.