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TIMP-3 expression in gastric cancer. Immunohistochemical detection of TIMP-3 in nonneoplastic gastric foveloar epithelium (A) and well-differentiated intestinal-type cancer (B). Poorly differentiated intestinal-type cancer (C) and diffuse-type gastric cancers (D) frequently demonstrated loss of TIMP-3 expression. Hematoxylin counterstain. Original magnifications, x200.
