Table 1.

TIMP-3 Expression in Both Cohorts and Correlation of TIMP-3 Expression with Clinicopathological Features.

	Cohort 1				Cohort 2
	All Cases	TIMP-3-Negative	TIMP-3-Positive	P	All Cases	TIMP-3-Negative	TIMP-3-Positive	P
All cases	176 (100%)	30 (17%)	146 (83%)		171 (100%)	47 (27.5%)	124 (72.5%)
Age
≤65 years	84 (47.7%)	14 (16.7%)	70 (83.3%)	1.000*	94 (55%)	25 (26.6%)	69 (73.4%)	0.864*
>65 years	92 (52.3%)	16 (17.4%)	76 (82.6%)		77 (45%)	22 (28.6%)	55 (71.4%)
Tumor stage
T1	19 (10.8%)	2 (10.5%)	17 (89.5%)	0.142†	8 (4.6%)	0 (0%)	8 (100%)	0.312†
T2	75 (42.6%)	11 (14.7%)	64 (85.3%)		80 (46.8%)	22 (27.5%)	58 (72.5%)
T3	72 (40.9%)	14 (19.4%)	58 (80.6%)		68 (39.8%)	21 (30.9%)	47 (69.1%)
T4	10 (5.7%)	3 (30%)	7 (70%)		15 (8.8%)	4 (26.7%)	11 (73.3%)
Nodal status
N0	49 (28.3%)	5 (10.2%)	44 (89.8%)	0.090†	36 (21.1%)	8 (22.2%)	28 (77.8%)	0.208†
N1	64 (37%)	12 (18.8%)	52 (81.2%)		64 (37.4%)	17 (26.6%)	47 (73.4%)
N2	37 (21.4%)	5 (13.5%)	32 (86.5%)		51 (29.8%)	14 (27.5%)	37 (72.5%)
N3	23 (13.3%)	7 (30.4%)	16 (69.6%)		20 (11.7%)	8 (40%)	12 (60%)
State of metastasis
M0	150 (85.2%)	22 (14.7%)	128 (85.3%)	0.052*	156 (91.2%)	44 (28.2%)	112 (71.8%)	0.763*
M1	26 (14.8%)	8 (30.8%)	18 (69.2%)		15 (8.8%)	3 (20%)	12 (80%)
Grade
G1	3 (1.7%)	0 (0%)	3 (100%)	0.003†	2 (1.2%)	0 (0%)	2 (100%)	0.012†
G2	49 (27.8%)	2 (4.1%)	47 (95.9%)		43 (25.1%)	6 (14%)	37 (86%)
G3	124 (70.5%)	28 (22.6%)	96 (77.4%)		126 (73.7%)	41 (32.5%)	85 (67.5%)
Lauren
Intestinal	107 (63.3%)	12 (11.2%)	95 (88.8%)	0.006‡	90 (52.6%)	13 (14.4%)	77 (85.6%)	<0.001‡
Mixed	0 (0%)	/	/		69 (40.4%)	27 (39.1%)	42 (60.9%)
Diffuse	62 (36.7%)	18 (29%)	44 (71%)		12 (7%)	7 (58.3%)	5 (41.7%)

P values were calculated for each cross-table correlation separately in the respective subgroups.

^*Fisher's exact test.

^†χ² test for trends.

^‡χ² test.