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. 2008 Jun;10(6):604–612. doi: 10.1593/neo.08356

Figure 5.

Figure 5

Tetraploid cells develop a higher number of numerical and structural chromosomal abnormalities over time in culture when compared with diploid cells. Spectral karyotyping (SKY) was used to assess numerical and structural abnormalities in SF3061-Vector and isolated diploid and tetraploid cells from SF3061-HES1 stable cell populations. (A) Representative SKY metaphases from control nonneoplastic arachnoid (Arachnoid) cells, SF3061-Vector (Diploid), and SF3061-HES1 (Tetraploid) cells are shown. (B and C) SKY karyograms of a diploid metaphase from SF3061-Vector cells at passage 19 (B) and a tetraploid metaphase from SF3061-HES1 cells at passage 19 (C) are shown. Chromosome numbers (white) are indicated.