Table 1. Cell Cycle analysis of SKOV-3 after Fe-SP treatment.
Fe-SP | SP | Ctr. | |||||||
Sub- | Sub- | ||||||||
G0/G1 | S | G2/M | G0/G1 | G0/G1 | S | G2/M | G0/G1 | ||
[%] | [%] | [%] | [%] | [%] | [%] | [%] | [%] | ||
No Drug | 75.0 | 22.1 | 2.9 | 1.2 | 72.5 | 24.0 | 3.5 | 1.2 | |
24 h | 0.4 µM | 73.8 | 19.4 | 6.9 | 7.2 | 73.8 | 20.9 | 5.3 | 0.8 |
0.8 µM | 44.7 | 28.0 | 13.9 | 5.8 | 71.2 | 22.9 | 5.9 | 3.9 | |
1.6 µM | 24.6 | 75.4 | 0 | 16.7 | 72.2 | 21.7 | 6.1 | 0.5 | |
No Drug | 74.4 | 16.5 | 9.0 | 0.3 | 71.6 | 17.8 | 10.7 | 0.3 | |
48 h | 0.4 µM | 65.5 | 22.3 | 12.3 | 9.8 | 68.9 | 19.8 | 11.3 | 0.7 |
0.8 µM | 43.3 | 40.9 | 16.3 | 17.3 | 70.0 | 18.4 | 11.6 | 1.5 | |
1.6 µM | 12.9 | 87.1 | 0 | 15.8 | 73.0 | 16.4 | 10.6 | 1.0 |
Cell cycle analysis was carried out as described (Materials and Methods). SKOV-3 cells were treated with 0, 0.4, 0.8 and 1.6 µM Fe-SP or SP (Ctr.) for 24 or 48 h. Data were obtained by FACS analysis based on propidium-iodide intercalation into cellular chromatin.