Table 1. Cell Cycle analysis of SKOV-3 after Fe-SP treatment.

			Fe-SP				SP	Ctr.
					Sub-				Sub-
		G0/G1	S	G2/M	G0/G1	G0/G1	S	G2/M	G0/G1
		[%]	[%]	[%]	[%]	[%]	[%]	[%]	[%]
	No Drug	75.0	22.1	2.9	1.2	72.5	24.0	3.5	1.2
24 h	0.4 µM	73.8	19.4	6.9	7.2	73.8	20.9	5.3	0.8
	0.8 µM	44.7	28.0	13.9	5.8	71.2	22.9	5.9	3.9
	1.6 µM	24.6	75.4	0	16.7	72.2	21.7	6.1	0.5
	No Drug	74.4	16.5	9.0	0.3	71.6	17.8	10.7	0.3
48 h	0.4 µM	65.5	22.3	12.3	9.8	68.9	19.8	11.3	0.7
	0.8 µM	43.3	40.9	16.3	17.3	70.0	18.4	11.6	1.5
	1.6 µM	12.9	87.1	0	15.8	73.0	16.4	10.6	1.0

Cell cycle analysis was carried out as described (Materials and Methods). SKOV-3 cells were treated with 0, 0.4, 0.8 and 1.6 µM Fe-SP or SP (Ctr.) for 24 or 48 h. Data were obtained by FACS analysis based on propidium-iodide intercalation into cellular chromatin.