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. 2008 May 30;4(5):e1000080. doi: 10.1371/journal.ppat.1000080

Figure 4. UL49.5 is responsible for TAP-inhibition in virus-infected natural host cells.

Figure 4

Bovine cells (MDBK), porcine cells (PK15), and equine cells (E.derm) were infected with wild type BHV-1, PRV, or EHV-1, respectively, or with the corresponding UL49.5-negative recombinant viruses. In all experiments, mock-treated (uninfected) cells from the relevant host species were used as a control. Peptide transport was assessed at 5 hrs post-infection in the presence and absence of ATP (black and open bars, respectively). The data are expressed as percentage of translocation, relative to the translocation observed in control cells (defined as 100%).