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. Author manuscript; available in PMC: 2009 Apr 21.
Published in final edited form as: J Theor Biol. 2007 Dec 23;251(4):628–639. doi: 10.1016/j.jtbi.2007.12.009

Figure 5. Predictions of models that contain parameter vectors identified by inversion of the simulated data shown in Figure 2.

Figure 5

(A) Simulated methionine (Metin, black line) and homocysteine (Hcyin, blue line) influx perturbations used to generate the output shown in the other panels. (B) Metabolite concentration responses. (C, D) Homocysteine methylation reaction flux (VMS + VBHMT) response. In panels (B) – (D), blue lines show the output of the reference model; grey lines (N = 200) show the output of the models containing the newly identified parameter vectors. The parameter vectors used in (B) and (C) were identified by inversion of concentration data only, and in (D) by inversion of both concentration and flux data.