Table 1.
Characteristics, urinary hormones, and salivary insulin levels in children of women with PCOS and control children
| Female
|
Male
|
|||||
|---|---|---|---|---|---|---|
| PCOS (n = 17) | Control (n = 21) | P value | PCOS (n = 15) | Control (n = 17) | P value | |
| Birth data | ||||||
| Gestational age (wk) | 40.0 (1.8) | 39.1 (1.8) | 0.14 | 40.1 (1.3) | 40.3 (0.9) | 0.73 |
| Birth weight (lb) | 7.7 (1.3) | 7.4 (1.4) | 0.57 | 8.3 (1.4) | 8.4 (1.0) | 0.88 |
| Biometric | ||||||
| Age (yr) | 9.1 (3.4) | 9.5 (3.0) | 0.74 | 9.7 (3.4) | 8.8 (3.0) | 0.40 |
| BMI (kg/m2) | 20.0 (5.3) | 18.8 (3.3) | 0.42 | 20.9 (5.1) | 19.4 (3.3) | 0.33 |
| Waist to hip ratio | 0.8 (0.1) | 0.8 (0.1) | 0.30 | 0.9 (0.1) | 0.8 (0.0) | 0.59 |
| Systolic blood pressure (mm Hg) | 109.1 (12.2) | 108.3 (10.6) | 0.84 | 110.6 (18.1) | 107.4 (9.9) | 0.54 |
| Diastolic blood pressure (mm Hg) | 66.7 (8.8) | 63.6 (6.5) | 0.24 | 65.6 (8.5) | 64.8 (7.5) | 0.77 |
| Reproductive (3-h timed urinary collections) | ||||||
| LH (mIU/h) | 190.9 (319.8) | 413.7 (882.9) | 0.34 | 137.7 (174.0) | 78.5 (59.3) | 0.23 |
| FSH (mIU/h) | 260.6 (205.4) | 358.7 (316.2) | 0.30 | 197.9 (177.8) | 161.1 (73.7) | 0.47 |
| Testosterone (ng/mg creatinine) | 21.5 (10.5) | 20.1 (13.9) | 0.75 | 30.3 (21.0) | 17.9 (17.2) | 0.09 |
| DHEA (ng/mg creatinine) | 3.3 (2.5) | 2.3 (2.5) | 0.28 | 1.9 (1.8) | 1.1 (1.1) | 0.16 |
| Metabolic (salivary insulin levels during OGTT) | ||||||
| Fasting insulin (μU/ml) | 9.1 (5.5) | 7.3 (3.3) | 0.26 | 9.5 (6.6) | 6.7 (2.0) | 0.14 |
| Insulin at 30 min (μU/ml) | 9.4 (5.2) | 8.0 (3.9) | 0.38 | 12.5 (8.4) | 8.6 (5.0) | 0.13 |
| Insulin at 60 min (μU/ml) | 24.6 (16.2) | 16.0 (6.5) | 0.06 | 20.5 (14.8) | 16.3 (11.2) | 0.38 |
| Insulin at 90 min (μU/ml) | 23.1 (16.3) | 15.4 (9.9) | 0.11 | 16.6 (14.5) | 15.6 (11.3) | 0.84 |
| Insulin at 120 min (μU/ml) | 25.0 (17.4) | 14.0 (6.9) | 0.03 | 16.7 (12.8) | 15.5 (17.2) | 0.82 |
| AUC insulin (min × μU/ml) | 2229.4 (1248.0) | 1495.0 (635.4) | 0.04 | 1881.0 (1266.7) | 1551.2 (1006.3) | 0.43 |
Values are expressed as mean (sd). Conversion factors to International System of Units: testosterone × 3.467 (nmol/liter), DHEA × 3.47 (nmol/liter), glucose × 0.0551 (mmol/liter), and insulin × 7.175 (pmol/liter).