Table 1.

Blood and urine biochemical and hormonal variables in 8 XLH subjects treated on day 1 with phosphate alone, on day 2 with phosphate + cinacalcet, and at follow-up after chronic treatment with phosphate + calcitriol

Treatment	Oral Phosphate: Day 1		Oral Phosphate + Cinacalcet: Day 2		Follow-up: Period E (oral phosphate + calcitriol)	Normal Range
	Period A: 0 h	Period B: 4 h	Period C: 0 h	Period D: 4 h
Ca2+ (mmol/L)	1.28 ± 0.03	1.23 ± 0.04	1.26 ± 0.04	1.13 ± 0.06c	1.24 ± 0.07	1.13–1.37
Phosphate (mg/dl)	2.1 ± 0.4	3.1 ± 0.4b	2.2 ± 0.5	3.4 ± 0.3e	2.9 ± 0.6b	2.9–4.9
PTH (pg/ml)	36 ± 19	53 ± 13c	34 ± 6	23 ± 8c	33 ± 15	7–75
FGF23 (pg/ml)	147 ± 90	149 ± 67	192 ± 120d	221 ± 91d	247 ± 195d	9–53
1,25 vitamin D (pmol/L)	67 ± 35	75 ± 44	13 ± 21d	17 ± 25d	14 ± 6d	35–84
TP/GFR (mg/dl)	1.70 ± 0.38	1.81 ± 0.42	1.73 ± 0.36	2.48 ± 0.39c	1.86 ± 0.71	2.8–4.7
Ca/creatininea (mg/mg)	0.12 ± 0.08	0.06 ± 0.04	0.13 ± 0.08	0.10 ± 0.08	0.14 ± 0.05	<0.20

^aMeasured in 6 subjects.

^bP < 0.05 versus A, C.

^cP < 0.05 versus all other groups.

^dP < 0.05 versus A, B.

^eP < 0.05 versus A, C, E (P = 0.06 versus B).