Figure 1.

Decreased GFR is associated with increased circulating advanced glycation end products (AGE), increased peripheral blood mononuclear cell (PBMC) receptor for AE (RAGE) mRNA, and decrease endothelial reactivity. (A and B) Relationship between Modification of Diet n Renal Disease (MDRD) GFR and serum ^ɛN-carboxymethyl-lysine (sCML; A) and RAGE (B). (C and D) Relationship between MDRD GFR and postocclusive reactive hyperemia (PORH; C) and thermal hyperemia (TH; D), both indices of endothelial reactivity. All correlation analyses were performed using Pearson coefficient.